منابع مشابه
Chromosome breakage and repair.
FROM time to time one of my colleagues working at a medical school commiserates with me because I spend 40 hr a year lecturing to undergraduates. I always reply that teaching has compelled me to learn a lot of material that I would not have known about had I taught only my specialized subject. These forays into the ‘‘beyond’’ were instrumental in moving my research in new directions. Three arti...
متن کاملChromosome breakage and ultrasound.
Human lymphocyte cultures were examined for chromosome damage after exposure to ultrasound. Control and treated slides were scored "blind" and showed no evidence of damage due to ultrasound. Neither was there evidence of chromosome damage in blood cultures from six infants whose mothers had ultrasound during pregnancy when compared with that from six infants whose mothers had not. Our results s...
متن کاملSterility, chromosome breakage, x-ray induced mutation rates and detected mutation frequencies in Drosophila melanogaster.
AMONG the enduring problems of radiation genetics is the quantitative evaluation of mutational damage elicited in germ cells that have been exposed to a given dose of radiation. The significant question at issue is what proportion of all irradiated germ cells actually suffer an induced mutation, i.e., what is the mutation rate? This is the question that must be accurately answered before the co...
متن کاملThe Fragile Breakage versus Random Breakage Models of Chromosome Evolution
For many years, studies of chromosome evolution were dominated by the random breakage theory, which implies that there are no rearrangement hot spots in the human genome. In 2003, Pevzner and Tesler argued against the random breakage model and proposed an alternative "fragile breakage" model of chromosome evolution. In 2004, Sankoff and Trinh argued against the fragile breakage model and raised...
متن کاملChromosome breakage following G2 checkpoint release
DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability. Ataxia telangiectasia (AT) cells have checkpoint arrest and DSB repair defects. Here, we examine the efficiency and interplay of ATM's G2 checkpoint and repair functions. Artemis cells manifest an identical and epistatic repair defect to AT but show proficient checkpoint ...
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ژورنال
عنوان ژورنال: Hereditas
سال: 2010
ISSN: 0018-0661
DOI: 10.1111/j.1601-5223.1949.tb03329.x